- Case Report
- Three Cases of the Letterer-Siwe Disease.
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M H Kim, E K Choi, M Y Chung, D H Keum
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Clin Exp Pediatr. 1985;28(8):817-822. Published online August 31, 1985
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Letterer-Siwe disease was an established entity with the following fature: occurrence in infancy, hepatosplenomegaly, lymphadenopathy, bleeding diathesis, tumors of bone, generalized hyperplasia of nonlipid storing macrophages in many organs but prominently in skin, and rapidly fatal downhill course.
The diognosis was confirmed by clinical symptoms, laboratory data, histopathologic and radiologic findings.
During past 6 years, we experienced 3 cases of the disease... |
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- The Kocher-Debre-Semelaigne Syndrome.
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M Y Chung, S I Kwon, S J Lee, D H Kum
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Clin Exp Pediatr. 1982;25(1):92-96. Published online January 31, 1982
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A 4-year old girl with the Kocher-Debre-Semelaigne syndrome, hypothyroidism with generalized muscular hypertrophy is described. Histologic examination of a calf muscle showed musclular hypertrophy with focal eosinophilic degeneration. The stigmas of hypothyroidism and the muscular hypertrophy disappeared promptly and concomitantly following therapy with desiccated thyroid. Similar cases reported in literature are briefly reviewed. The clinical and histologic changes of the... |
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